Research
We actively lead and participate in clinical trials in Intestinal Failure.
Current clinical trials:
EASE SBS 2/3 (Efficacy and Safety Evaluation of Glepaglutide in Treatment of SBS)
EASE SBS1 (Efficacy And Safety Evaluation of Glepaglutide in SBS)
Efficacy and Safety of Apraglutide in SBS-IF (STARS)
Information Needs around Parenteral nUTrition in cancer - INPUT study
Phase 3 extension trial of Glepaglutide in patients with SBS.
A Prospective, Multi-center Registry for Patients With Short Bowel Syndrome
Publications:
Oral, Enteral and Parenteral Nutritional Therapies in Scleroderma: a Systematic Review. Clinical Nutrition ESPEN. 2022.
Keane N, Ghannam A, Fragkos KC, Rahman F.
A retrospective analysis of malnutrition risk, nutritional support and outcomes in COVID-19 patients. Clin Nutr ESPEN. 2022 Aug;50:196-206
Bell J, Heyer N, Greenstein A, Fragkos K, Baxter-Derrington C, Mehta S.
The Role of Diet and Gut Microbiota in Regulating Gastrointestinal and Inflammatory Disease. Frontiers in Immunology. 2022:1495.
Gill PA, Inniss S, Kumagai T, Rahman FZ, Smith AM.
P5 Risk factors associated with intestinal failure in crohn’s disease patients: a retrospective cohort study. BMJ Publishing Group; 2022.
Al-Shakarchi N, Khetan T, Fragkos KC, Rahman F.
Bedside post-pyloric enteral tube placement using Kangaroo IRIS technology: a single centre case series Nutrition 2021 Feb 11;86:111195
Cardona E, Mehta SJ
P280 The clinical significance of hypophosphataemia after intravenous iron infusions for iron deficiency anaemia. Gut. 2021;70(1):A1-A262.
Sehgal V, Fragkos K, Rogers J, Arulrajan S, Pavanerathan P, Barragry J, Sebepos-Rogers G, Mehta S, Di Caro S, Rahman F.
P145 Biologics are inferior to surgery in isolated internal penetrating Crohn’s disease: a single centre experience. BMJ Publishing Group; 2021.
Sebepos-Rogers G, Al-Shakarchi N, Khetan T, McCartney S, Bloom S, Seward E, Vega R, Rahman F, Mehta S.
The role of the microbiome in gastrointestinal inflammation. Bioscience Reports. 2021;41(6).
Sanders DJ, Inniss S, Sebepos-Rogers G, Rahman FZ, Smith AM.
Clinical and nutritional care pathways of patients with malignant bowel obstruction: a retrospective analysis in a tertiary UK center. Nutrition and Cancer. 2021;73(4):572-87.
Patel PS, Fragkos KC, Keane N, Cauldwell K, O’Hanlon F, Rogers J, Obbard S, Barragry J, Sebepos-Rogers G, Neerkin J.
Home parenteral nutrition in patients with advanced cancer: a systematic review and meta-analysis. Nutrition and Cancer. 2021;73(6):943-55.
O’Hanlon FJ, Fragkos KC, Fini L, Patel PS, Mehta SJ, Rahman F, Di Caro S.
37 CLINICAL OUTCOMES OF PATIENTS ON HOME PARENTERAL NUTRITION DISCUSSED OR REFERRED FOR SMALL BOWEL TRANSPLANT: PRELIMINARY DATA. Digestive and Liver Disease. 2021;53:S153-S4.
Mazzara R, Plyta M, Fragkos K, Crutchley G, Jacinto T, Holmes E, Keane N, Mehta S, Rahman F, Gambassi G. AF.
COVID‐19 infection in patients with intestinal failure: U.K. experience
Journal of Parenteral and Enteral Nutrition doi.org/10.1002/jpen.2087
Allan PJ, Ambrose T, Mountford C, Bond A, Donnellan C, , Boyle R, Calvert C, Cernat E, Clarke E, Cooper SC, Donnelly S, Evans B, Glynn M, Hewett R, Holohan AS, Leitch EF, Louis-Auguste J, Mehta S, Naik S, Nightingale J, Rafferty G, Rodrigues A, , Sharkey L, Small M, Teubner A, Urs A, Wyer N, Lal S
Gastrointestinal consequences of cancer treatment: evaluation of 10 years’ experience at a tertiary UK centre. Frontline Gastroenterology. 2021;12(6):471-7.
Gadhok R, Paulon E, Tai C, Olushola T, Barragry J, Rahman F, Di Caro S, Mehta S.
PSY7 Increased Length and Cost of Hospital Stay in Inpatients with Iron Deficiency Anemia Experiencing Moderate-Severe Hypophosphatemia after Administration of Ferric Carboxymaltose. Value in Health. 2021;24:S230.
Fragkos K, Pollock R, Sehgal V, Rahman F.
P277 Nutritional status and disease activity in crohn’s disease: preliminary data. BMJ Publishing Group; 2021.
Fonalleras-Marcos D, Fragkos K, Vega R, McCartney S, Parisi I, Seward E, Bloom S, Mehta S, Rahman F, DiCaro S.
PMO-18 Intestinal failure in crohn’s disease: A systematic review and meta-analysis of surgical risk factors. Gut. 2021;70(Suppl 4):A85-A6.
Al-Shakarchi N, Nolan R, Khetan T, Fragkos KC, Rahman F.
Nutritional status and COVID-19: an opportunity for lasting change?
Clin Med (Lond). 2020 Apr 27:clinmed.2020-0187. doi: 10.7861/clinmed.2020-0187.
Mehta S.
Nutritional Status and Quality of Life in Hospitalised Cancer Patients Who Develop Intestinal Failure and Require Parenteral Nutrition: An Observational Study. Nutrients. 2020;12(8):2357.
Plyta M, Patel PS, Fragkos KC, Kumagai T, Mehta S, Rahman F, Di Caro S.
Chronic sleep disturbance in patients on home parenteral nutrition: a prospective study of prevalence and patient-reported barriers. Clinical Nutrition ESPEN. 2020;40:527-8.
Gu Y, Fragkos K, Keane N, Rogers J, Di Caro S, Rahman F, Mehta S.
Adipose tissue imaging as nutritional predictors in patients undergoing enterocutaneous fistula repair. Nutrition. 2020;73:110722.
Fragkos KC, Thong D, Cheung K, Thomson HJ, Windsor AC, Engledow A, McCullough J, Mehta SJ, Rahman F, Plumb AA.
Hypophosphataemia after intravenous iron therapy with ferric carboxymaltose—Real world experience from a tertiary centre in the UK. GastroHep. 2020;2(5):205-14.
Fragkos KC, Sehgal V, Rogers J, Arulrajan S, Pavanerathan P, Barragry J, Sebepos‐Rogers GM, Mehta SJ, Di Caro S, Rahman F.
When is parenteral nutrition indicated in the hospitalized, acutely ill patient? Current Opinion in Gastroenterology. 2020;36(2):129-35.
Fragkos KC, Sebepos-Rogers G, Rahman F.
Serum scoring and quantitative magnetic resonance imaging in intestinal failure-associated liver disease: a feasibility study. Nutrients. 2020;12(7):2151.
Fragkos KC, Picasso Bouroncle MC, Kumar S, Caselton L, Menys A, Bainbridge A, Taylor SA, Torrealdea F, Kumagai T, Di Caro S.
Nutritional status and disease activity in Crohn's disease: Preliminary data. Clinical Nutrition ESPEN. 2020;40:470.
Fonalleras-Marcos D, Fragkos K, Vega R, McCartney S, Parisi I, Seward E, Bloom S, Mehta S, Rahman F, Di Caro S.
How effective is our monitoring of patients on parenteral nutrition? Clinical Nutrition ESPEN. volume 35, P212-213, February 01, 2020. DOI:https://doi.org/10.1016/j.clnesp.2019.12.015
R. Bradshaw, J. Fegredo, C. Ferreira, I. Barbaso, V. Maher, I. Nasr.
SUN-LB662: Nutritional Status and Anthropometrical Measurements in Cancer Patients Referred for Inpatient Parenteral Nutrition: Preliminary Analyses from a UK Tertiary Referral Centre. Clinical Nutrition. 2019;38:S305.
Plyta M, Patel P, Keane N, Holmes E, Fragkos K, Sebepos-Rogers G, Barragry J, Rogers J, Crutchley G, Jacinto T.
Su2021–Is Home Parenteral Nutrition Burdersome in Advanced Cancer Patients with Malignant Bowel Obstruction? a Retrospective Analysis in a Uk Intestinal Failure Centre. Gastroenterology. 2019;156(6):S-693.
Patel PS, Keane N, Cauldwell K, Fragkos KC, O’Hanlon F, Rogers J, Obbard S, Sebepos-Rogers G, Barragry J, Mehta S.
PWE-004 Does robotic surgery lead to more patients requiring parenteral nutrition? analysis in a tertiary centre. A. Bancil, S. Boyer-Masfari, I. Nasr. Gut 2019;68:A175.
Su2020–Nutritional Care Pathways of Patients with Malignant Bowel Obstruction: Experience from a Uk Tertiary Referral Centre. Gastroenterology. 2019;156(6):S-692-S-3.
Patel PS, Fragkos KC, Keane N, Cauldwell K, O’Hanlon F, Rogers J, Obbard S, Sebepos-Rogers G, Barragry J, Mehta S.
PWE-014 Is home parenteral nutrition burdensome in advanced cancer patients with malignant bowel obstruction? : BMJ Publishing Group; 2019.
Patel P, Keane N, Fragkos K, O’Hanlon F, Cauldwell K, Rogers J, Obbard S, Barragry J, Sebepos-Rogers G, Mehta S.
MON-PO399: Nutritional Care Pathways of Patients with Malignant Bowel Obstruction: Preliminary Findings from 8 UK Centres. Clinical Nutrition. 2019;38:S206.
Patel P, Fragkos K, Keane N, Mountford C, Wilkinson D, Johnson A, Naghibi M, Chan D, Roberts B, Neild P.
MON-PO400: Parenteral Nutrition in Patients with Malignant Bowel Obstruction: Preliminary Findings from 8 UK Centres: Are all Patients Referred Appropriately? Clinical Nutrition. 2019;38:S206-S7.
Patel P, Fragkos K, Keane N, Mountford C, Wilkinson D, Johnson A, Naghibi M, Chan D, Roberts B, Neild P.
OWE-17 Nutritional care pathways of patients with malignant bowel obstruction: preliminary findings from 8 UK Centres. BMJ Publishing Group; 2019.
Patel P, Fragkos K, Keane N, Mountford C, Wilkinson D, Johnson A, Naghibi M, Chan D, Roberts B, Neild P.
MON-PO401: Nutritional Care Pathways of Patients with Malignant Bowel Obstruction: Experience from a UK Tertiary-referral Centre. Clinical Nutrition. 2019;38:S207.
Patel P, Fragkos K, Keane N, Cauldwell K, O’Hanlon F, Rogers J, Obbard S, Barragry J, Sebepos-Rogers G, Mehta S.
PWE-013 Nutritional care pathways of patients with malignant bowel obstruction: experience from a UK tertiary-referral centre. BMJ Publishing Group; 2019.
Patel P, Fragkos K, Keane N, Cauldwell K, O’Hanlon F, Rogers J, Obbard S, Barragry J, Sebepos-Rogers G, Mehta S.
PT11. 06: Is Home Parenteral Nutrition Burdensome in Advanced Cancer Patients with Malignant Bowel Obstruction? A Retrospective Analysis in an UK Intestinal Failure Centre. Clinical Nutrition. 2019;38:S58.
Patel P, Fragkos K, Keane N, Cauldwell K, O’hanlon F, Rogers J, Obbard S, Barragry J, Sebepos-Rogers G, Mehta S.
Refeeding syndrome in adults receiving total parenteral nutrition: an audit of practice at a tertiary UK centre. Clinical Nutrition. 2019;38(3):1457-63.
Pantoja F, Fragkos KC, Patel PS, Keane N, Samaan MA, Barnova I, Di Caro S, Mehta SJ, Rahman F.
Home parenteral nutrition with an omega-3-fatty-acid-enriched MCT/LCT lipid emulsion in patients with chronic intestinal failure (the HOME study): study protocol for a randomized, controlled, multicenter, international clinical trial. Trials. 2019;20(1):1-11.
Klek S, Chambrier C, Cooper SC, Gabe S, Kunecki M, Pironi L, Rahman F, Sobocki J, Szczepanek K, Wanten G.
Response to Letter re: Refeeding syndrome in adults receiving total parenteral nutrition: An audit of practice at a tertiary UK centre. Clinical Nutrition. 2019;38(2):968-.
Fragkos KC, Di Caro S, Mehta SJ, Rahman F.
Enteral nutrition in adult Crohn’s disease: Toward a paradigm shift. Nutrients. 2019;11(9):2222.
Di Caro S, Fragkos KC, Keetarut K, Koo HF, Sebepos-Rogers G, Saravanapavan H, Barragry J, Rogers J, Mehta SJ, Rahman F.
Needs-based quality of life in adults dependent on home parenteral nutrition. Clinical Nutrition. 2019;38(3):1433-8.
Burden ST, Jones DJ, Gittins M, Ablett J, Taylor M, Mountford C, Tyrrell-Price J, Donnellan C, Leslie F, Bowling T.
Randomised clinical trial: 2% taurolidine versus 0.9% saline locking in patients on home parenteral nutrition. Alimentary pharmacology & therapeutics. 2018;48(4):410-22.
Wouters Y, Theilla M, Singer P, Tribler S, Jeppesen PB, Pironi L, Vinter‐Jensen L, Rasmussen H, Rahman F, Wanten G.
Composite serum liver Fibrosis/Cirrhosis scores may be associated with parenchymal liver disease in patients with chronic intestinal failure. Clinical Nutrition. 2018;37:S300.
Picasso M, Fragkos K, Di Caro S, Rahman F, McNaughton J, Mehta S.
The use of standard parenteral nutrition bags in advanced cancer patients. Clinical Nutrition. 2018;37:S290-S1.
Patel P, Fragkos K, Keane N, Murray K, Obbard S, Mehta S, Rahman F, Di Caro S.
The microbiome and radiation induced-bowel injury: evidence for potential mechanistic role in disease pathogenesis. Nutrients. 2018;10(10):1405.
Kumagai T, Rahman F, Smith AM.
Performance status, prognostic scoring, and parenteral nutrition requirements predict survival in patients with advanced cancer receiving home parenteral nutrition. Nutrition and Cancer. 2018;70(1):73-82.
Keane N, Fragkos KC, Patel PS, Bertsch F, Mehta SJ, Di Caro S, Rahman F.
Care pathway for patients with advanced gynaecological cancer and bowel obstruction: Preliminary data. Clinical Nutrition ESPEN. 2018;28:257-8.
Keane N, Fragkos KC, Mehta S, Rahman F, Di Caro S.
P. 10.7 PARENTERAL NUTRITION IN PATIENTS WITH MALIGNANT BOWEL OBSTRUCTION SECONDARY TO ADVANCED GYNAECOLOGICAL CANCER. Digestive and Liver Disease. 2018;50(2):e230-e1.
Keane N, Fragkos K, Rahman F, Mehta S, Di Caro S.
Small intestinal bacterial overgrowth, sepsis and diet affect liver function tests (LFTS) in home parenteral nutrition (HPN) patients: A Uk single-centre analysis. Clinical Nutrition. 2018;37:S188-S9.
Keane N, Fragkos K, Di Caro S, Mehta S, Rahman F.
OTU-025 Gastrointestinal consequences of cancer: an evaluation of ten years experience at a tertiary centre. BMJ Publishing Group; 2018.
Gadhok R, Paulon E, Tai C, Rahman F, Di Caro S, Mehta S.
Risk factors for catheter related bloodstream infections in patients on home parenteral nutrition: An audit from a tertiary center in 2017. Clinical Nutrition. 2018;37:S297.
Fragkos KC, Murray K, Obbard S, Shepherd T, Barragry J, Nwaogu A, Rogers J, Ajibodu S, Keane N, Patel P.
Malabsorption and artificial nutrition in patients with gut GvHD post allogenic stem cell transplantation: Home parenteral nutrition affects survival significantly. Clinical Nutrition. 2018;37:S307.
Fragkos KC, Kwok H, Bhakta A, Keane N, Chakraverty R, Thomson K, Rahman F, Di Caro S, Mehta S.
Predicting 3-and 6-month survival for advanced cancer patients on home parenteral nutrition: A nomogram. Clinical Nutrition ESPEN. 2018;28:258-9.
Fragkos KC, Keane N, Patel PS, Murray K, Obbard S, Ajibodu S, O’Callaghan S, Kwok H, Paulon E, Barragry J.
A systematic review of home parenteral nutrition in patients with advanced cancer. Clinical Nutrition ESPEN. 2018;28:258.
Fragkos KC, Fini L, Keane N, Kwok H, Paulon E, Barragry J, Mehta S, Rahman F, Di Caro S.
Lean body mass in computed tomography as a marker of nutritional status in enterocutaneous fistulae: A cross sectional study. Clinical Nutrition ESPEN. 2018;28:259.
Fragkos KC, Cheung K, Thong D, Keane N, Mehta S, Rahman F, Plumb A, Di Caro S.
OC. 06.4 LEAN BODY MASS AT L3-IMAGING AS A NEW MARKER OF NUTRITIONAL STATUS IN ENTEROCUTANEOUS FISTULAE. Digestive and Liver Disease. 2018;50(2):e82.
Fragkos K, Thong D, Keane N, Mehta S, Rahman F, Di Caro S.
Rate of readmissions for advanced cancer patients on home parenteral nutrition: A surrogate marker of quality of life. Clinical Nutrition. 2018;37:S308.
Fragkos K, Patel P, Keane N, Assoku M, Baptista A, Murray K, Obbard S, Shepherd T, Barragry J, Nwaogu A.
Taurolidine Locking Prevents Catheter-Related Bloodstream Infections in Patients on Home Parenteral Nutrition: a Randomized Controlled Trial. United European Gastroenterology Journal. 2017;5(Suppl. 1):A834.
Wouters Y, Theilla M, Singer P, Tribler S, Jeppesen P, Pironi L, Vinter-Jensen L, Rasmussen H, Rahman F, Wanten G.
PT10. 2: Re-Feeding Syndrome in Adults Receiving Total Parenteral Nutrition: An Audit in a Highly Specialized Intestine Failure Unit. Clinical Nutrition. 2017;36:S50-S1.
Pantoja F, Patel P, Keane N, Fragkos K, Samaan M, Barnova I, Di Caro S, Mehta S, Rahman F.
MON-P096: Biochemical Measurements as a Predictor of Survival in Patients with Incurable Cancers Receiving Home Parenteral Nutrition (HPN). Clinical Nutrition. 2017;36:S215.
Keane N, Fragkos K, Patel P, Murray K, Obbard S, Ajibodu S, O’callaghan S, Kwok H, Paulon E, Barragry J.
P220 Current practices in Ileal pouch surveillance for ulcerative colitis patients in Three London IBD referral centres. Journal of Crohn's and Colitis. 2017;11(suppl_1):S188-S9.
Kabir M, Morgan S, Samaan M, Forsyth K, Segal J, Elkady S, Arenaza A, Kok K, Seward E, Vega R.
Magnesium sulphate allergy and subsequent tolerance to magnesium chloride in a patient with intestinal failure. Clinical and Experimental Allergy; 2017: WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA.
Fragkos K, Mehta S, Di Caro S, Rahman F, Dziadzio M, Lukawska J, editors.
MON-P294: Magnesium Sulphate Allergy and Subsequent Tolerance to Magnesium Chloride in a Patient with Intestinal Failure. Clinical Nutrition. 2017;36:S287.
Fragkos K, Mehta S, Di Caro S, Rahman F, Dziadzio M, Lukawska J.
SUN-P150: Predicting 3 and 6-Month Survival for Advanced Cancer Patients on Home Parenteral Nutrition: A Nomogram. Clinical Nutrition. 2017;36:S109-S10.
Fragkos K, Keane N, Patel P, Murray K, Obbard S, Ajibodu S, O’callaghan S, Kwok H, Paulon E, Barragry J.
PTU-109 Home parenteral nutrition in patients with advanced cancer: a systematic review. BMJ Publishing Group; 2017.
Fragkos K, Fini L, Keane N, Kwok H, Paulon E, Barragry J, O’Hanlon F, Mehta S, Rahman F, Di Caro S.
SUN-P114: home parenteral nutrition in patients with advanced cancer: a systematic review. Clinical Nutrition. 2017;36:S96.
Fragkos K, Fini L, Keane N, Kwok H, Paulon E, Barragry J, Mehta S, Rahman F, Di Caro S.
SUN-P207: Towards a New Marker of Nutritional Status in Enterocutaneous Fistulae: Lean Body Mass in CT. Clinical Nutrition. 2017;36:S130-S1.
Fragkos K, Cheung K, Thong D, Keane N, Mehta S, Rahman F, Plumb A, Di Caro S.
MON-P068: An updated audit of home parenteral nutrition (hpn) in palliative oncology patients-A UK single centre case series with survival analysis. Clinical Nutrition. 2016;1(35):S178.
Keane N, Fragkos K, Patel P, Obbard S, Murray K, Guilvezan S, O'Hanlon F, Kok K, Paulon E, Di Caro S.
SUN-P254: Micronutrient Profiles in Home Parenteral Nutrition Patients. Clinical Nutrition. 2016;1(35):S138-S9.
Fragkos K, Huang J, Keane N, Patel P, Murray K, Obbard S, Guilvezan S, O'Hanlon F, Kok K, Paulon E.
MON-P055: A Retrospective Study of the Management of Pancreatic Exocrine Insufficiency at University College London Hospital (UCLH). Clinical Nutrition. 2016;1(35):S173-S4.
Chen K, Keane N, Fragkos K, DiCaro S, Mehta S, Rahman F, Saravanapavan H, Grimble G, Patel P.
PTH-208 Home parenteral nutrition (HPN) in palliative oncology patients-a UK single centre case series with survival analysis. Gut. 2015;64:A501.
Keane N, Bertsch F, Patel P, Fragkos K, Barnova I, Samaan M, Morgan S, Smith L, Babbington M, Di Caro S.
PTH-200 amino acid profiles in patient with intestinal failure: preliminary data on biochemical insights. BMJ Publishing Group; 2015.
Fragkos K, Samaan M, Morgan S, Barnova I, Smith L, Babington M, Patel P, Keane N, Rahman F, Di Caro S.
Incidence and Severity of Pre-pouch Ileitis: A Distinct Disease Entity or a Manifestation of Refractory. JOURNAL OF CROHNS & COLITIS; 2015: OXFORD UNIV PRESS GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND.
de Jong D, Samaan M, Sahami S, Morgan S, Fragkos K, Subramaniam S, Kok K, Makanyanga J, Barnova I, Saravanapavan H, editors.
PTH-197 Significant reduction in catheter-related bloodstream infections in high risk adult patients on home pn or iv fluids after introduction of secondary prophylaxis with taurolidine-citrate line lock. BMJ Publishing Group; 2015.
Barnova I, Fragkos K, Morgan S, Smith L, Saravanapavan H, Samaan M, Patel P, Keane N, Babington M, Di Caro S.
PP071-MON: Home Parenteral Nutrition in Palliative Cancer Patients in the UK. Clinical Nutrition. 2014(33):S156.
Bertsch F, Forbes A, Rahman F.
PP102-SUN: Adjustment of Malnutrition Screening in an Oncology Outpatient Setting. Clinical Nutrition. 2014(33):S57-S8.
Bertsch F, Allen E, Montanheiro K, Forbes A, Rahman F.